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University Animal Care (UAC) provides consultation to investigators on rodent breeding colony management, offers rodent breeding colony management services, and coordinates specialized husbandry needs for individual rodent breeding colonies.

Consultation prior to breeding colony establishment is required to identify husbandry needs for the colony and to develop a colony-specific standard operating procedure (SOP). The IACUC requires the UAC Breeding Colony Supervisor’s signature on all breeding protocols and addenda. Consultation is also strongly encouraged if production is less than anticipated to identify potential factors that may be adversely impacting production and to discuss strategies to improve production.

Typical rodent breeding colony management services include setting up breeding groups (pairs, trios, harems), weaning, and separating offspring into groups by sex and parental source.  UAC also maintains breeding records for colonies that are fully managed by UAC.  Special services such as timed-matings, vaginal plug checks, and daily checks for new litters are available on a fee for service basis.  If an investigator wishes UAC to fully manage their rodent breeding colony or has special requests of UAC for investigator-managed colonies, inquiries should be made to the breeding colony supervisor.

Specialized husbandry and breeding colony management duties are conveyed to UAC husbandry personnel through the use of detailed colony-specific SOPs and also through the use of quick reference cards that are maintained in each room.  These clearly delineate the responsibilities of UAC husbandry personnel, and are prepared by the breeding colony supervisor in consultation with the investigator. Our mission is to provide efficient, cost effective, high quality rodent breeding and related services to the research community while maintaining the highest Quality Assurance and customer service standards.

Please contact the UAC Breeding Colony Supervisor for consultation, special needs, and to report problems related to rodent breeding to Cindy Richner or (520) 626-6270.


Links to information on rodent genetics, reproductive biology, breeding, and colony management:

http://www.informatics.jax.org/ Mouse genome informatics website also has links to online books.

http://www.mmrrc.org/ Mutant Mouse Regional Resource Centers. I copied the following off their website: The MMRRC program is sponsored by the National Center for Research Resources (NCRR) at the National Institutes of Health (NIH, DHHS). The purpose of the program is to ensure the continued availability of scientifically valuable, genetically engineered mice and to distribute these mice to qualified researchers studying human and animal biology and disease. A national network of regional breeding and distribution centers serves as NIH's premier repository of spontaneous and induced mutant mouse lines.

http://www.taconic.com/library/biblio.htm Good resource links, journal articles and reproductive characteristics for their mouse models.

http://jaxmice.jax.org/info/index.html. Comprehensive information on inbred and genetically altered mice from the world’s leading resource for these mice, The Jackson Laboratories.

http://knockout.cwru.edu/services/musfrming.html Frequently Asked Questions (FAQs) about breeding mice.

http://www.ncbi.nlm.nih.gov/genome/guide/mouse/ NCBI mouse genome website with links to mutant mouse repositories and mouse genome resources.

http://www.rgs.uci.edu/ular/mousebreeding/performance.htm.  Factors that affect breeding performance


Powerpoint presentation on rodent genetics presented as part of the UAC seminar series by Dr. David Besselsen in October 2002.  Includes brief reviews of genetics, the use of the mouse in genetics research, and rodent genetic terminology and nomenclature. Click here to view presentation.

Powerpoint presentation on rodent reproductive biology presented as part of the UAC seminar series by Dr. Paula Johnson in October 2002.  Includes pictures for estimating the gestational stage of pregnant female mice and the age of neonatal mice. Click here to view presentation (This file is slow in opening)

Powerpoint presentation on rodent breeding colony management presented as part of the UAC seminar series by Ms. Cindy Richner in October 2002.  Includes advantages and disadvantages associated with various rodent breeding schemes. Click here to view presentation.


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