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Changes to Requirements in Documentation
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| Recently, the UA was visited
by the United States Department of Agriculture Animal Care Veterinarian.
The visit included inspection of the animal facilities and records.
The inspector indicated that our current IACUC protocol form is not
specific enough to ensure that the search for alternative techniques
(3R’s: Replace, Reduce, Refine) is adequately addressed. She also
did not find evidence in most protocols that databases specifically
geared to address alternatives were commonly used by researchers at the
UA. To address the concerns, which could result in citations for violation of the Animal Welfare Act, the IACUC is requiring that all literature searches performed after AUGUST 1, 2006, must include at least one search engine that can address alternative techniques. Examples of acceptable data bases include: $ ALTWEB: http://altweb.jhsph.edu/ Alternatives to Animal Testing on the Web serves as a gateway to alternatives news, information and resources on the Internet and elsewhere. $ ALTBIB: http://toxnet.nlm.nih.gov/altbib.html This site is under the National Library for Medicine. $ AnimAlt-ZEBET Database: http://www.dimdi.de/static/en/db/index.htm This German site provides a full-text database of alternative methods (3Rs) to animal experiments in biomedicine and related fields (Click on Databases, then Databases A-Z, and then on AnimAlt-ZEBET) $ ECVAM SIS(Scientific Information Service) Database: http://www.nc3rs.org.uk/category.asp?catID=3 Provides factual and evaluated information on advanced non-animal methods for toxicology assessments; offers full method descriptions, including development and validation status. $ INVITRODERM: http://www.invitroderm.com/ Provides alternatives to skin irritation/corrosion testing in animals. ALTWEB Pain Management (Anaesthesia/Analgesia) Database: http://apps1.jhsph.edu/altweb/aadb/aadb_search.cfm Information about anesthesia and analgesia for most commonly used laboratory animals.
$
ALTWEB Humane Endpoints Database:
http://apps1.jhsph.edu/altweb/humane/ $ European Resource Centre for Alternatives in Higher Education (EURCA): http://www.nc3rs.org.uk/category.asp?catID=3 Information about alternatives to using animals in higher education.The following sites can help you develop strategies for searching for alternatives and can link you to data bases that will perform the searches: $ Animal Welfare Information Center: Alternatives: http://riley.nal.usda.gov/nal_display/index.php?info_center=3&tax_level=1&tax_subject=183. This site provides many avenues to consider for searches and gives information on how to design your search for alternatives. $ Databases section of the University of California Center for Animal Alternatives (UCCAA) website: http://www.vetmed.ucdavis.edu/Animal_Alternatives/database.htm $ FRAME Guide to Searching for Alternatives: http://www.frame.org.uk/Searching%20for%20Information/Search%20Guide%20Index.htm. f you have questions regarding this new requirement, please contact one of the following individuals: Susan Wilson-Sanders, IACUC member: 626-1066wilson-s@u.arizona.edu Paula Johnson, IACUC member: 621-3483 |
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